Dr. Majd Mahdavi




Majid Mahdavi
Associate Professor of Biochemistry
Tel: +98-21-61113452
E-mail:: majidmahdavi@ut.ac.ir, maj.mahdavi@gmail.com
Scopus Author ID: 11541162200
ORCID: 0000-0003-0041-0440

   Majid Mahdavi currently works at the Molecular Biology Laboratory. Majid does research in Cancer field. The primary focus of our research lab is investigating molecular mechanisms of tumor development and progression. We have applied different human cancer cell lines to comprehensively understand the cell death signal transduction pathways in order to integrate this knowledge into strategies to effectively and specifically kill cancer cells for therapeutically purposes.




Personal Records                                                



Name: Majid Mahdavi       
Date of Birth: 28 March 1981            
Place of Birth: Najaf Abad, Isfahan, Iran.           
Marital Status: Married, 2 Children
Appointment: Associate Professor 
Office Address: Molecular Biology Laboratory, Institute of Biochemistry and Biophysics, University of Tehran P.O.Box 13145-1384 Tehran, Iran.    
Telephone: (+98)021-61113446-021-66969190
Fax: (+98)-21- 66404680
E-Mail: majidmahdavi@ut.ac.ir
Visiting PhD student for a year period, October 2011
Department of Molecular Life Sciences, University of Zurich (UZH), Zurich, Switzerland.
Ph.D.  (2007-2011) Biochemistry
Institute of Biochemistry and Biophysics (IBB), University of Tehran, Iran.
M.Sc.  (2003-2006) Biochemistry
Institute of Biochemistry and Biophysics (IBB), University of Tehran, Iran.
B.Sc.  (1999-2003) Biology Faculty of science, University of Kharazmi, Tehran, Iran.


Research Interests

Currently, we are working on the cytotoxicity, apoptosis-inducing activity and molecular docking of the different synthetic compounds, mimetic compounds, antibiotics, nanoparticles, as well as natural products (from medicinal plants and Bacteria) in human cancer cells. We are working on the effect of antibiotics and also natural products on various cancer cell lines and animal model, as well as evaluation of their molecular mechanism in human cancer cells. 

Skills and Expertise

Natural products Isolation and Purification

DNA, RNA and Protein extraction

Agarose gel electrophoresis, SDS-PAGE

Cell Culture

Fluorescent Microscopy

Flow cytometry

Western Blotting


Animal Models


Leila Parsa, Rouhollah Motafakkerazad, Sarvin Taleb Soheyli, Morteza Kosari Nasab, Majid Mahdavi *. Silymarin in combination with ATRA enhances apoptosis induction in human acute promyelocytic NB4 cells. Toxicon 2023 (IF: 3. 03).
Masumeh Babayi, Mohammed Ashtiani, Amirhossein Emamian, Hosseinali Ramezanpour, Hashem Yousefi, Majid Mahdavi. Peri-implant Cell Differentiation in Delayed and Immediately-loaded Dental Implant: a Mechanobiological Simulation. Archives of Oral Biology 2023 (IF: 2.64), 10.1016/j.archoralbio.2023.105702.
Khudhair Rashid Khudhair Alzubaidi, Majid Mahdavi *, Sanam Dolati, Mehdi Yousefi. Observation of increased levels of autophagy-related genes and proteins in women with preeclampsia: a clinical study. 
Molecular Biology Reports 2023 (IF: 2.74), 10.1007/s11033-023-08385-6.
Mohammad Sobhan Karvandi, Farzam Sheikhzadeh Hesari, Amir Reza Aref, Majid Mahdavi *. The Neuroprotective Effects of Targeting Key Factors of Neuronal Cell Death in Neurodegenerative Diseases: The Role of ER Stress, Oxidative Stress, and Neuroinflammation. Frontiers in Cellular Neuroscience 2023 (IF: 6.14), 10.3389/fncel.2023.1105247
Oskouei, B., Dehghan, G., Majid Mahdavi , Feizi, M.A.H. Preparation and characterization of novel antimicrobial Cu-Al layered double hydroxide filled polyvinyl alcohol/chitosan nanofibers with peroxidase-mimic activity. Applied Clay Science 2023 (IF: 5.9), 237, 106914.


1. Tehrani Fateh S, Shekari F, Mahdavi M, Aref AR, Salehi-Najafabadi A. The Effects of Sesquiterpene Lactones on the Differentiation of Human or Animal Cells Cultured In-Vitro: A Critical Systematic Review. Frontiers in Pharmacology (IF: 6. 1). 13, 10.3389/fphar.2022.862446.


2. Khadijeh Dizaji Asl; Ali Rafat; Behnaz Valipour; Zeinab mazloumi; Ali Akbar Movassaghpour; Mehdi Talebi; Mahdavi M; Hamid Tayefi Nasrabadi, Hojjatollah Nozad Charoudeh. Cord blood stem cell-generated KIR+NK cells effectively target leukemia cell lines. Human Immunology (IF: 2.2), 2022, 14 Nov.


3. Novinbahador T, Araj-Khodaei, Mahdavi M*. Evidence for Hesperidin as an Effective Factor in Initiating the Intrinsic Pathway of Apoptosis in KG1a Leukemia Cells.

International Journal of Toxicology (IF: 2.3), 2022. 9 Dec. 10.1177/10915818221146468.



4. Ali Shamsazar, Asad Asadi, Davood Seifzadeh, Mahdavi M*. A sandwich-type electrochemical immunosensor based on a novel strategy for signal amplification using MWCNTS/Fe3O4 nanocomposite for ultrasensitive determination of PSA biomarker. Sensor & Actuator B: Chemical, 346, 130459 (IF: 9. 2).


5. Soleimanian A, Khalilzadeh B, Mahdipour M, Aref AR, Ebrahimi-W M, Rashidi MR, Mahdavi M*. Graphene quantum dots based ultrahigh-sensitive electrochemical cytosensor for detection of acute myeloid leukemia stem cells. IEEE Sensors Journal 2021 (IF: 4.3), 99: 1, 10.1109/JSEN.2021.3079224.


6. Sahar Porrang, Nader Rahemi, Soodabeh Davaran, Mahdavi M, Belal Hassanzadeh. Preparation and in-vitro evaluation of mesoporous biogenic silica nanoparticles obtained from rice and wheat husk as a biocompatible carrier for anti-cancer drug delivery. European Journal of Pharmaceutical Sciences, 2021 (IF: 5. 2). 10.1016/j.ejps.2021.105866.

7. Sahar Porrang, Nader Rahemi, Soodabeh Davaran, Mahdavi M, Belal Hassanzadeh, Amin Mohammad Gholipour. Direct surface modification of mesoporous silica nanoparticles by DBD plasma as a green approach to prepare dual-responsive drug delivery system. Journal of the Taiwan Institute of Chemical Engineers (IF: 5.4), 2021, 10.1016/j.jtice.2021.05.024.


8. Hanifeh Ahagh M, Dehghan GR, Mahdavi M, Hosseinpour Feizi, Teimuri-Mofrad R, Payami  E, Mehdipour M, Rashtbari S. DNA binding ability and cytotoxicity, cell cycle arrest and apoptosis inducing properties of a benzochromene derivative against K562 human leukemia cells. Nucleosides Nucleotides & Nucleic Acids, 2021. 40(7):732-753. (IF: 1.5).


9. Mirzaahmadi, A, Hosseini-Yazdi, S.A., Mahdavi M., Eigner, V., Dušek, M, Poupon, M. Apoptotic induction in K562 cell line by new water-soluble complexes of nickel(II) and zinc(II). Polyhedron (IF: 2.8) 2021, 10.1016/j.poly.2021.115205.

Porrang, Nader Rahemi, Soodabeh Davaran, Mahdavi M, Belal Hassanzadeh. Synthesis of temperature/pH dual-responsive mesoporous silica nanoparticles by surface modification and radical polymerization for anti-cancer drug delivery. 2021, Colloids and Surfaces A: Physicochemical and Engineering Aspects (IF: 5.5) 623(2):126719. DOI: 10.1016/j.colsurfa.2021.126719



10. Farhad Eslami, Majid Mahdavi*, Esmaeil Babaei, Bashdar Mahmud Hussen, Hossein Mostafavi, Ahmad Shahbazi. Down-regulation of Survivin and Bcl-2 concomitant with the activation of caspase-3 as a mechanism of apoptotic death in KG1a and K562 cells upon exposure to a derivative from ciprofloxacin family, Toxicology and Applied Pharmacology (IF: 4.4), 2020. Doi: 10.1016/j.taap.2020.115331.


11. Dizaji Asl K, Velaei K, Rafat A, Tayefi Nasrabadi H, Movassaghpour AA, Mahdavi M, Nozad charoudeh H. The role of KIR positive NK cells in diseases and its importance in clinical intervention. International Immunopharmacology (IF: 5.7) 2020, 92(1):107361 .


12. Rabiei M, Zarrini G, Mahdavi M. Isolation and Characterization of Lactobacillus paracasei ST1 from Region of Azerbaijan "Shoor" Dairy Product and Study of Anticancer and Anti-Proliferation Activities by Supernatant of Strain on HCT116 Colorectal Tumor Cells In Vitro. Jundishapur j Cell Mol Biology, 2020, Doi: 10.5812/jjcmb.107803.


13. Ghorbani Parsa F, Hosseinpour-Feizi MA, Hosseini-Yazdi, SA, Mahdavi M*. Molecular mechanisms of apoptosis induction in K562 and KG1a leukemia cells by a water-soluble copper(II) thiosemicarbazone complex. Journal of Biological Inorganic Chemistry (JBIC, IF: 3.8) 2020, Doi: 10.1007/s00775-020-01769-0.

14. Ghaderi S, Babaei 1E, Bashdar MH, Mahdavi M, Azeez HJ. M. Gemini Curcumin Suppresses Proliferation of Ovarian Cancer OVCAR-3 Cells via Induction of Apoptosis. Anticancer Agents Med Chem (IF; 2.5). 2020. doi: 10.2174/1871520620666200807223340.


15. Shabani F, Mahdavi M*, Imani M, Hosseinpour-Feizi MA, Gheibi N. Calprotectin (S100A8/S100A9) induced cytotoxicity and apoptosis in human gastric cancer AGS cells: Alteration in expression levels of Bax, Bcl-2, and ERK2. Hum Exp Toxicol (IF: 3.2). 2020 Mar 13:960327120909530. doi: 10.1177/0960327120909530.


16. Sardroud, S.J., Hosseini-Yazdi, S.A., Mahdavi M., Poupon, M., Skorepova, E. Synthesis, characterization and in vitro evaluation of anticancer activity of a new water-soluble thiosemicarbazone ligand and its complexes. Polyhedron (IF: 2.8) 2020, 175,114218


17. Samarkhazan NS, Yekta R, Sayadi M, Tackallou SH, Safaralizadeh R, Mahdavi M*. 2-NDC from dithiocarbamates improves ATRA efficiency and ROSinduced apoptosis via downregulation of Bcl2 and Survivin in human acute promyelocytic NB4 cells. Hum Exp Toxicol (IF: 3.2). 2020 Feb 25. doi: 10.1177/0960327120905958.


18. Haddadi, P., Mahdavi M*, Rahbarghazi, R. Down-regulation of Bcl2 and Survivin, and up-regulation of Bax involved in copper (II) phenylthiosemicarbazone complex-induced apoptosis in leukemia stem-like KG1a cells. Process Biochemistry (IF: 4.8), 2020, 92; 190-196.


19. Khosravifar, F., Dehghan, G., Bidoki, S.K., Mahdavi M. DNA-binding activity and cytotoxic and cell-cycle arrest properties of some new coumarin derivatives: a multispectral and computational investigation. Luminescence (IF: 2.6), 2020, 35(1), pp. 98-106.


20. Rabiei M, Zarrini G, Mahdavi M. Lactobacillus casei UT1 Isolated from Northwest of Iran Traditional Curd Exerts Anti-proliferative and Apoptosis Inducing Effects in Human Colorectal Tumor HCT 116 Cells. Adv Pharm Bull (IF: 2.5), 2020 Jan;10(1):125-129.


21. Daryabari SS, Fathi M, Mahdavi M, Moaddab Y, Hosseinpour Feizi MA, Shokoohi B, Safaralizadeh R. Overexpression of CFL1 in gastric cancer and the effects of its silencing by siRNA with a nanoparticle delivery system in the gastric cancer cell line. J Cell Physiol (IF: 6.5), 2020 Jan 28. doi: 10.1002/jcp.29562.


22. Alimohammadi, A., Mostafavi, H., Mahdavi M. Thiourea Derivatives Based on the Dapsone-Naphthoquinone Hybrid as Anticancer and Antimicrobial Agents: In Vitro Screening and Molecular Docking Studies. Chemistry Select (IF: 1.8), 2020, 5(2), pp. 847-852.



23. Khani-Meinagh H, Mostafavi H, Reiling N, Mahdavi M, Zarrini G. Design, synthesis and evaluation of biological activities of some novel anti-TB agents with bio-reducible functional group. Bioimpacts (IF: 3.1), 2019;9(4):199-209. doi: 10.15171/bi.2019.25.


24. Miandashti, N., Safaralizadeh, R., Hosseinpourfeizi, M.A., Mahdavi M. Neuroprotective effect of cannabidiol on NTF-3 and IGF-1 genes expression. Indian Journal of Traditional Knowledge 2019, 18(4), pp. 739-743.


25. Beignezhad H, Mohammadzadeh M, Mahdavi M*, Mostafavi H. Study of cytotoxicity and cell death of an active compound from prazinoic acids in chronic myeloid leukemia K562 cell line. Medical Journal of Tabriz University of Medical Science & Health Service 2019, 41: 14-21.


26. Faramarzi L, Dadashpour M, Sadeghzadeh H, Mahdavi M, Zarghami N. Enhanced anti-proliferative and pro-apoptotic effects of metformin encapsulated PLGA-PEG nanoparticles on SKOV3 human ovarian carcinoma cells. Artif Cells Nanomed Biotechnol (IF: 6.3). 2019 Dec;47(1):737-746.


27. Rahimian A, Mahdavi M*, Rahbarghazi R, Charoudeh HN. 4t-CHQ a Spiro-Quinazolinone Benzenesulfonamide Derivative Induces G0/G1 Cell Cycle arrest and Triggers Apoptosis Through Down-Regulation of Survivin and Bcl2 in the Leukemia Stem-Like KG1-a Cells. Anticancer Agents Med Chem (IF: 2.5), 2019 Mar 13. doi: 10.2174/1871520619666190313165130.


28. Mehdipour M, Dehghan G, Yekta R, Hanifeh Ahagh M, Mahdavi M, Ghasemi Z, Fathi Z. DNA-binding affinity, cytotoxicity, apoptosis, cell cycle inhibition and molecular docking studies of a new stilbene derivative. Nucleosides Nucleotides Nucleic Acids (IF: 1.6). 2019 Mar 31:1-18.



29. Dehghan Nayeri MJ, Mahdavi M*, Fazeli H, Hosseinpourfeizi, M.A., Apoptosis Inducing Effect Of Spiroaminopyrimidine Analogue In NB4 Leukemia Cells Via Down-Regulation Of BIRC5 Expression. Experimental Oncology (IF: 1.1), 2019, 41(2):1-6. Doi: 10.32471/exp-oncology.2312-8852.vol-41-no-4.13749



30. Mina Karimpour, Mohammad Ali Hosseinpour Feizi, Majid Mahdavi, Barbara Krammer, Thomas Verwanger, Farhood Najafi, Esmaeil Babae. Development of curcumin-loaded gemini surfactant nanoparticles: synthesis, characterization and evaluation of anticancer activity against human breast cancer cell lines. Phytomedicine (IF: 6.6). 2018, doi: 10.1016/j.phymed.2018.11.017.


31. Mohammad Alizadeh E, Mahdavi M, Jenani Fard F, Chamani S, Farajdokht F, Karimi P. Metformin protects PC12 cells against oxygen-glucose deprivation/reperfusion injury. Toxicology mechanisms and methods (IF: 4.1). 2018, DOI: 10.1080/15376516.2018.1486495.


32. Shabani F, Farasat A, Mahdavi M, Gheibi N. Calprotectin (S100A8/S100A9): a key protein between inflammation and cancer. Inflammation Res (IF: 6.9). 2018, 67(10):801-812. Doi: 10.1007/s00011-018-1173-4.


33. Mostafavi H, Mahdavi M, Hossein Khani- Meinagh. Synthesis and biological evaluation of some novel 2-pyrazinoic acid- derived esters. Letters in Organic Chemistry (IF: 0.8), 2018, DOI: 10.2174/1570178615666180806122226.


34. Rabiei M, Zarrini GR, Mahdavi M. Cytotoxic Effects of Lactobacilli Isolated from Azerbaijan Traditional Cheeses on Colorectal Tumor Cells HCT 116 and Identification of Paramount Strains. 2018, DOI: 10.29252/jarums.18.2.191.


35. Rahnamay M, Mahdavi M*, Rashidi MR, Hosseinpour Feizi MA. Cytotoxic and apoptosis inducing effect of some 4-H pyrano [3, 2-c] pyridine derivatives against human MCF-7 Breast Cancer Cells. Acta Biochimica Polonica (IF: 2.5), 2018;65(3):397-402. doi: 10.18388/abp.2017_1629.


36. Mahdavi M*, Asghari S, Rahnamay M, Dehghan GR, Hosseinpour Feizi MA, Balalaie S. Cytotoxicity, oxidative stress and apoptosis in K562 leukemia cells induced by an active compound from pyrano-pyridine derivatives. Human & Experimental Toxicology (IF: 3.2), 2018, 37(10):1105-1116, DOI: 10.1177/0960327118756719.



37. Hosseini-Yazdi, S.A. , Mirzaahmadi, A., Khandar, A.A., Mahdavi, M., Rahimian, A., Eigner, V., Dušek, M., Zarrini, GR. Copper, nickel and zinc complexes of a new water-soluble thiosemicarbazone ligand: Synthesis, characterization, stability and biological evaluation. Journal of Molecular Liquids (IF: 6.6), 2017, 248, pp. 658-667.


38. Arami S, Mahdavi M*, Rashidi MR, Yekta R, Rahnemay M, Molavi L, Hejazi MS, Samadi N. Apoptosis induction activity and molecular docking studies of survivin siRNA carried by Fe3O4-PEG-LAC-chitosan-PEI nanoparticle in MCF-7 human breast cancer cells. Journal of Pharmaceutical and Biomedical Analysis (IF: 3.57), 2017 Aug 5;142:145-154.



39. Arami S, Mahdavi M*, Rashidi MR, Molavi L, Hejazi MS, Samadi N. Multifunctional superparamagnetic nanoparticles: from synthesis to siRNA delivery. Current pharmaceutical design (IF: 2.5), 2017;23(16):2400-2409.


40. Hasanzadeh D, Mahdavi M*, Dehghan GR, Nozad Charoudeh H. Farnesiferol C induces cell cycle arrest and apoptosis mediated by oxidative stress in MCF-7 cell line. Toxicology Reports (IF: 4.8), 2017 Aug 1;4: 420-426.


41. Hosseini-Yazdi, S.A., Mirzaahmadi, A., Khandar, A.A., Eigner, V., Dušek, M., Mahdavi, M., Soltani, S., Lotfipour, F., White, J. Reactions of copper(II), nickel(II), and zinc(II) acetates with a new water-soluble 4-phenylthiosemicarbazone Schiff base ligand: Synthesis, characterization, unexpected cyclization, antimicrobial, antioxidant, and anticancer activities. Polyhedron (IF: 2.8), 2017, 124, pp. 156-165.


42. Hosseini-Yazdi, S.A., Mirzaahmadi, A., Khandar, A.A., Eigner, V., Dušek, M., Lotfipour, F., Mahdavi, M., Soltani, S., Dehghan GR. Synthesis, characterization and in vitro biological activities of new water-soluble copper(II), zinc(II), and nickel(II) complexes with sulfonato-substituted Schiff base ligand. Inorganica Chimica Acta (IF: 3.1), 2017, 458, pp. 171-180.



43. Mahdavi M*, Mohseni Lavi M, Yekta R, Nobarani M, Balalei S, Rashidi MR. Evaluation of the cytotoxic, apoptosis inducing activity and molecular docking of spiroquinazolinone benzamide derivatives in MCF-7 breast cancer cells. Chemico-Biological Interactions (IF: 5.1), 2016, 260, pp. 232-242.


44. Khoshtabiat L, Mahdavi M*, Dehghan GR, Rashidi MR. Oxidative stress-induced apoptosis in chronic myelogenous leukemia K562 cells by an active compound from dithio-carbamate family. Asian Pacific Journal of Cancer Prevention (IF: 1.7), 2016, 17 (9), pp. 4267-4273.


45. Arami S, Mahdavi M*, Rashidi MR, Molavi L, Hejazi MS, Samadi N. Novel polyacrylate-based cationic nanoparticles for survivin siRNA delivery combined with MTX for treatment of breast cancer. Biologicals (IF: 2.0), 2016, 44 (6), pp. 487-496.


46. Arami S, Rashidi MR, Mahdavi M, Fathi M, Entezami AA. Synthesis and characterization of Fe3O4-PEG-LAC-chitosan-PEI nanoparticle as a surviving siRNA delivery system. Human &Experimental Toxicology (IF: 3.2). 2016, 36 (3), pp 227-237.


47. Ravanbakhsh A, Mahdavi M*, Jalilzade-Amin G, Javadi Sh, Maham M, Mohammadnejad D, Rashidi MR. Acute and subchronic toxicity study of the median septum of Juglans regia L. in rat. Advanced Pharmaceutical Bulletin (IF: 2.2). 2016, 6 (4), pp. 541-549.



48. Cheraghi O, Dehghan GR, Mahdavi M, Rahbarghazi R, Rezabakhsh A, Nozad Charoudeh H, Iranshahi M, Montazersaheb S. Potent anti-angiogenic and cytotoxic effect of conferone on human intestinal adenocarcinoma cell line. Phytomedicine (IF: 4.2). 2016 Apr 15;23(4):398-405.



49. Dehkordi MF, Dehghan G, Mahdavi M, Hosseinpour Feizi MA. Investigation on the Binding Mode of 3, 4 Dihydropyrano [c] Chromene Derivative with Double Strand DNA. 2015, Advanced Pharmaceutical Bulletin (IF: 2.1). 01/2015; 5(3).


50. Laya Khoshtabiat, Mahdavi M*. The Role of Oxidative Stress in Proliferation and Cell Death. J Mazandaran Univ Med Sci.2015, 25: 230-245.


51. Mahdavi M*, Yekta R, Hesami Tackallou S. Review: Positive correlation between ELF and RF electromagnetic field on cancer risk. Journal of Paramedical Sciences. 2015, 6 (3): 1-7.


52. Mahdavi M*, Yekta R, Hesami Tackallou S. Review: Association between ELF and RF electromagnetic field and Leukemia. Journal of Paramedical Sciences. 2015, 6 (2): 1-10.


53. Naseri MH, Mahdavi M*, Davoodi J, Hesami tackallou S, Godarzvand M, Hallaj SH. Up regulation of Bax and down regulation of Bcl2 during 3-NC mediated apoptosis in human cancer cells. Cancer Cell International (IF: 6.4). 12/2015; 15(54). DOI:10.1186/s12935-015-0204-2.


54. Mahdavi M*, Pejman S, Rahimi R, Safaralizadeh R, Hosseinpour Feizi MA, Khosroushahi AY, Zare P. Inhibition of Growth and Induction of Differentiation and apoptosis in human leukemia K562 cells by a new compound from dihydropyrano[c]chromenes family. European Journal of Oncology. 01/2015; 20(n1).


55. Dehkordi MF, Dehghan G, Mahdavi M, Hosseinpour Feizi MA. Multispectral studies of DNA binding, antioxidant and cytotoxic activities of a new pyranochromene derivative. Spectrochim Acta A Mol Biomol Spectrosc (IF: 4.8). 2015 Jun 15;145: 353-9.



56. Ghasemian M, Mahdavi M*, Rahnamay M, Zare P, Hosseinpour Feizi MA, Balalae S. Cytotoxic and Apoptotic Effects of the New Derivatives of Quinazoline Family on K562 Cells, Chronic Myelogenous Leukemia. Medical Journal of Tabriz University of Medical Sciences & Healt, Oct/Nov 2014, 36 (4): 86 -91.


57. Mottaghi B, Safaralizadeh R, Jabbarpour Bonyadi M, Latifi-Navid S, Somi MH, Mahdavi M. Relationship of Helicobacter pylori vacA i1 and i2 alleles with gastric cancer risk, Iran: a brief report. Tehran University Medical Journal 12/2014; 72(9):638-642.



58. Alemi Serej F, Mahdavi M*, Zare P, Hosseinpour Feizi MA, Balalae S. Biological Evaluation of Aminopyrimidines Derivatives as Growth Inhibitor and Apoptosis Inducer of K562 Chronic Myeloid Leukemia Cells. J Mazandaran Univ Med Sci. 2014; 24 (116): 1-10.


59. Rahimi R, Mahdavi M*, Pejman S, Zare P, Balalaei S. Inhibition of cell proliferation and induction of apoptosis in K562 human leukemia cells by the derivative (3-NpC) from dihydro-pyranochromenes family. Acta biochimica Polonica (IF: 2.5), 02/2015; 62(1):83-88.


60. Ghasemian M, Mahdavi M*, Zare P, Hosseinpour Feizi MA. Spiroquinazolinone-induced cytotoxicity and apoptosis in K562 human leukemia cells: alteration in expression levels of Bcl-2 and Bax. The Journal of Toxicological Sciences (IF: 2.3). 2015; 40(1):115-126.


61. Naseri MH, Hesami tackallou S, Mahdavi M*, Moosavi MA, Abasalti S, Foroumadi A. Induction of Differentiation and Cell Death of the Derivative of 4-aryl-4HChromenes Family on NB4 Human Promyelocytic Leukemia Cell Line. Journal of Cell & Tissue. 2013; 4(2): 139-147.


62. Basiri Z, Safaralizadeh R, Jabbarpour Bonyadi M, Somi MH, Mahdavi M, Latifi-Navid S. Helicobacter pylori vacA d1 Genotype Predicts Risk of Gastric Adenocarcinoma and Peptic Ulcers in Northwestern Iran. Asian Pacific journal of cancer prevention (IF: 1.7), 2014; 15(4):1575-1579.



63. Pejman S, Mahdavi M*, Balalaei S. Growth inhibition and Induction of apoptosis in K562 Chronic Myeloid Leukaemia cells by the derivatives of dihydropyrano[c]chromenes family. Journals of Kermanshah University of Medical Sciences. 2013; 17(7): 404-413.


64. Marashi SA, Kouhestani H, Mahdavi M*. Studying the relationship between robustness against mutations in metabolic networks and lifestyle of organisms. The Scientific World Journal (IF: 1.5). 2013; ID: 615697, 6 Page.



65. Aryapour H, Mahdavi M*, Mohebbi S. R, Zali M.R, and Foroumadi A. Anti-proliferative and apoptotic effects of the derivatives from 4-aryl-4H-chromene family on human leukemia K562 cells. Arch Pharm Res (IF: 6.1). 2012, 35: 1573-82.


66. Aryapour H, Riazi G.H, Ahmadian S, Foroumad A, Mahdavi M, Emami S. Antitumor activity of chromene-based chalcones. Pharmaceutical Biology (IF: 3.8). 2012; 50(12): 1551–60.



67. Mahdavi M, Zali M.R, Foroumadi A and Davoodi J. Concomitant activation of caspase-9 and down-regulation of IAP proteins as a mechanism of apoptotic death in HepG2, HCT-116 and T47D cells upon exposure to a novel compound from 4-aryl-4H-chromenes family. Biomed & Pharmacother (IF: 7.4). 2011 Jun; 65:175-82.



68. Aryapour H, Riazi GH, Foroumadi AR, Ahmadian SH, Shafiee A, Karima O, Mahdavi M, Saeed Emami MS, Khodadady S. Biological evaluation of synthetic analogues of curcumin: chloro-substituted-20-hydroxychalcones as potential inhibitors of tubulin polymerization and cell proliferation. Med Chem Res (IF: 2.2). Published online: 23 March 2010.


69. Vosooghi M, Rajabalian S, Sorkhi M, Badinloo M, Nakhjiri M, Negahbani A.S, Asadipour A, Mahdavi M, Shafiee A, Foroumadi A. Synthesis and cytotoxic activity of some 2-amino-4-aryl-3-cyano-7-(dimethylamino)-4H-chromenes. Res in Pharmaceutical Sci (IF: 2.3), 2010 Jan;5(1):9-14.



70. Mahdavi, M, Yazdanparast, R. Gnidilatimonoein from Daphne mucronata induces differentiation and apoptosis in leukemia cell lines. Arch Pharm Res (IF: 6.1), 2007, 30, No 2, 177-181.



71. Yazdanparast, R, Mahdavi, M, Moosavi, M.A. Induction of Differentiation and Apoptosis in three Human Leukemia Cell Lines by a new compound from Dendrostellera lessertii. Acta Biochim Biophys Sin (IF: 2.5). 2006 Jul; 38(7): 477-83.


72. Yazdanparast, R. Moosavi, M.A, Mahdavi M, Lotfi A. Guanosine 5'-triphosphate induces differentiation-dependent apoptosis in human leukemia U937 and KG1 cells. Acta Pharmacol Sin (IF: 7.1). 2006 Sep; 27(9): 1175-84.



73. Yazdanparast R, Moosavi MA, Mahdavi M, Sanati MH. 3-Hydrogenkwadaphnin from Dendrostellera lessertii induces differentiation and apoptosis in HL-60 cells. Planta Med (IF: 2.9). 2005 Dec; 71(12):1112-7.



(All books published in Persian language)


1. Majid Mahdavi, Moosavi Mohammad Amin. Molecular Cell Biology and Genetic Engineering. Biology house Press, Tehran (From 2006-2022).


3. Majid Mahdavi, Sirus Khodadadi. Biochemistry. Biology house Press, Tehran (From 2012-2020).


4. Harvey Lodish et al. Molecular Cell Biology, (2013 & 2016 version). (Translated to Persian by Majid Mahdavi et al). Biology house Press, Tehran. 2013-2019.


5. Bruce Alberts et al. Essential Cell Biology, (2020, Fifth Edition). (Translated to Persian by Majid Mahdavi et al). Danesh-Pajohan Javan Press, Tehran. Under print.


Honors and Awards:

2006: Excellent student in MSc course and enter into Ph.D course on the basis of exceptional talents.

2006: Book of the Year Award: 14th Iranian student year book for Molecular cell biology and genetic engineering book. Honors and Awards (Continued): Journal Referee: Editorial Board:

2010: Young scientist award as a selected young researcher in the International Cell Death Symposium Kemer-Turkey.

2013: Young scientist award as a selected young researcher in the University of Tabriz.

2018: The Exemplary professor award in the University of Tabriz.

2020: Abu Reyhan Biruni's Award: Iranian Young Researchers in the field of Biology. The academy of Sciences, Department of Basic Sciences, Iran.

2020: Book of the Year Award: 2th East Azerbaijan year book for Molecular cell biology and genetic engineering book (3th Edition).



More than 50 master students in Biochemistry, Molecular Cell Biology and Genetics (University of Tabriz).

8 Ph.D students in Biochemistry, Drug Biotechnology and Genetics (University of Tabriz and Tabriz University of Medical Silences).

2 Ph.D students in Biochemistry  (University of Tehran).



Current Clinical Pharmacology

Current Reviews in Clinical and Experimental Pharmacology


MS.c Level.

Advanced Molecular Biology

Ph.D Level

Biochemistry of Signal transduction

Previous Teaching Experience (2012-2022; University of Tabriz)

BS.c: Biochemistry-I (Structure), Biochemistry-II (Metabolism), Oncology.

MS.c: Advanced Molecular Biology, Biochemistry of Chromatin, Biochemistry of Metabolism, Cellular Biochemistry

Ph.D: Biochemistry of Signal transduction, The Molecular and Cellular Basis of Cancer