Dr. Jamshid Davoodi Dr. Jamshid Davoodi


Jamshid Davoodi, Ph.D.
Assistant Professor   
Tel: +98-21-66969190, 61113446
E-mail: jdavoodi@ut.ac.ir                         
Professional Profile:
Career scientific professional with over 15 years of experience in biochemistry and biophysics, teaching at a university level, mentoring graduate students, laboratory management  and leadership, service in scientific societies, and international collaborations.


Personal Records :                                            
Name: Jamshid Davoodi               
Appointment: Assistant Professor
Office Address: Institute of Biochemistry and Biophysics,  
University of Tehran P.O.Box 13145-1384 Tehran,Iran    
Telephone: 0098 21 66969190  
Fax: 0098 21 66404680           
E-Mail: jdavoodi@ut.ac.ir
Web Site: ibb.ut.ac.ir/~davoodi









1996   Wake Forest University, USA
Postdoctoral Fellow
Overexpression and Characterization of Branched Chain Amino Transferases
Advisor: Dr. Susan Hutson
1995  University of Ottawa, Canada
• PhD in Biochemistry
Dissertation: "Bacillus circulans Xylanase, Stability and Mechanism of Action"
Advisors: Dr. Paul Carey, Dr. Witold Surewicz
1991  University of Tehran, Iran
MSc in Biochemistry
Dissertation: "Interaction of Doxorubicin with Chromatin"
Advisor: Azra Rabbani 
1989  University of Tabriz, Iran
BSc in Chemistry
  •  2005-current, Associate Professor of Biochemistry,  Institute of Biochemistry and Biophysics, University of Tehran, Tehran, Iran and affiliation as Research Assistant Professor from 2009 until 2014 with the Department of Human Nutrition, Foods and Exercise, Virginia Tech, Blacksburg, VA,
  •  2003-2005 Research Scientist and the Director of the Proteomics Laboratory Apoptosis Research center, Children's Hospital of Eastern Ontario, Ottawa, Ontario, Canada
  •  1997-2002 Research Associate, Molecular Genetics, Research Institute, Children's Hospital of Eastern Ontario, Ottawa, Ontario, Canada


Publications Publications

Full international papers
1. Shakeri R, Hosseinkhani S, Los MJ, Davoodi J, Jain MV, Cieślar-Pobuda A, Rafat M, Ardestani SK.  Role of the salt bridge between glutamate 546 and arginine 907 in preservation of autoinhibited form of Apaf-1. Int J Biol Macromol. 2015 Aug; 81:370-374 
2. Naseri MH, Mahdavi M, Davoodi J, Tackallou SH, Goudarzvand M, Neishabouri SH. Up regulation of Bax and down regulation of Bcl2 during 3-NC mediated apoptosis in human cancer cells. Cancer Cell Int. 2015 May; 15: 55-64
3. Neishabouri SH, Hutson SM and Davoodi J. Chronic Activation of mTOR Complex 1 by Branched Chain Amino Acids and organ hypertrophy, Amino Acids. 2015 June; 47: 1167-82
4. Soori H., Rabbani-Chadegani A and Davoodi J. Exploring binding affinity of oxaliplatin and carboplatin, to nucleoprotein structure of chromatin: Spectroscopic study and histone proteins as a target European Journal of Medicinal Chemistry, 2015 Jan, 89: 844-850
5. Cheraghi R, Hosseinkhani S, Davoodi J, Nazari M, Amini-Bayat Z, Karimi H, Shamseddin M, Gheidari F. Structural and functional effects of circular permutation on firefly luciferase: in vitro assay of caspase 3/7. Int J Biol Macromol. 2013 Jul;58: 336-42
6. Safavi M, Esmati N, Ardestani SK, Emami S, Ajdari S, Davoodi J, Shafiee A, Foroumadi A, Halogenated flavanones as potential apoptosis-inducing agents: Synthesis and biological activity evaluation. Eur J Med Chem. 2012 Dec; 58: 573-80 
7. Bagheri, S, Davoodi J, Saboury AA, and Salmanian AH. A mechanistic insight into caspase-7 inhibition by BIR1-2 domains of XIAP and cIAP1. Journal of the Iranian Chemical Society 2012; 9: 615-623.
8. Mahdavi M, Davoodi J, Zali MR, Foroumadi A. Concomitant activation of caspase-9 and down-regulation of IAP proteins as a mechanism of apoptotic death in HepG2, T47D and HCT-116 cells upon exposure to a derivative from 4-aryl-4H-chromenes family. Biomed Pharmacother. 2011 Jun; 65: 175-82.
9. Karimpour S, Davoodi J, Ghahremani MH. Integrity of ATP binding site is essential for effective inhibition of the intrinsic apoptosis pathway by NAIP. Biochem Biophys Res Commun. 2011 Apr 1; 407: 158-62.
10. Aliabadi A, Shamsa F, Ostad SN, Emami S, Shafiee A, Davoodi J, Foroumadi A.  Synthesis and biological evaluation of 2-phenylthiazole-4-carboxamide derivatives as anticancer agents. Eur J Med Chem. 2010 Nov; 45: 5384-9.
11. Davoodi J, Ghahremani MH, Es-Haghi A, Mohammad-Gholi A, Mackenzie A. Neuronal apoptosis inhibitory protein, NAIP, is an inhibitor of procaspase-9. Int J Biochem Cell Biol. 2010 Jun; 42: 958-64.
12. Abhari BA, Davoodi J. BIR2 domain of XIAP plays a marginal role in inhibition of executioner caspases. Int J Biol Macromol. 2010 Apr 1; 46: 337-41. 
13. Abkhezr M, Keramati AR, Ostad SN, Davoodi J, Ghahremani MH. The time course of Akt and ERK activation on XIAP expression in HEK 293 cell line. Mol Biol Rep. 2010 37: 2037-42. 
14. Sharifi AM, Eslami H, Larijani B, Davoodi J. (2009) Involvement of caspase-8, -9, and -3 in high glucose-induced apoptosis in PC12 cells. Neurosci Lett. 459: 47-51. 
15. Abhari, B.A. & Davoodi, J, A Mechanistic Insight into SMAC Peptide Interference with XIAP-Bir2 Inhibition of Executioner Caspases. Journal of Molecular Biology 2008; 381, 645–654.
16. Taghavi, M.H., Davoodi, J, Mirshahi, M. The effect of wild type p53 gene transfer on growth properties and tumorigenicity of PANC-1 tumor cell line. Iranian Biomedical Journal. 2007; 11: 1-6.
17. Taghavi, M.H. & Davoodi, J, Restoration of p53 functions suppresses tumor growth of pancreatic cells with different p53 status. Cancer Biother Radiopharm. 2007; 22:322-32.  
18. Davoodi J , Kelly J, Gendron NH, Mackenzie AE. The Simpson-Golabi-Behmel syndrome causative Glypican-3, binds to and inhibits the dipeptidyl peptidase activity of CD26. Proteomics. 2007; 7: 2300-10. 
19. Davoodi J, Mohammad-Gholi A, Es-Haghi A, MacKenzie A. W323S variant of Xiap-Bir3 binds to SMAC but not caspase-9. J. Biochem. 2007; 141: 293-9.
20. Taghavi, M.H., Mirshahi, M., Davoodi, J, Wild type p53 gene transfer increases chemosensitivity and apoptotic response of PANC-1 pancreatic tumor cell line. Iranian Journal of Biotechnology. 2006; 4: 112-116.
21. Davoodi J, Wakarchuk WW, Carey PR, Surewicz WK. Mechanism of stabilization of Bacillus circulans xylanase upon the introduction of disulfide bonds. Biophys Chem. 2007; 125: 453-61.
22. Davoodi J, Lin L, Kelly J, Liston P, MacKenzie AE. Neuronal apoptosis-inhibitory protein does not interact with Smac and requires ATP to bind caspase-9. J Biol Chem. 2004; 279: 40622-8. 
23. Maier JK, Lahoua Z, Gendron NH, Fetni R, Johnston A, Davoodi J, Rasper D, Roy S, Slack RS, Nicholson DW, MacKenzie AE. The neuronal apoptosis inhibitory protein is a direct inhibitor of caspases 3 and 7. J Neurosci. 2002; 22: 2035-43. 
24. Drown PM, Torres N, Tovar AR, Davoodi J, Hutson SM. Use of sulfhydryl reagents to investigate branched chain alpha-keto acid transport in mitochondria. Biochim Biophys Acta. 2000; 1468: 273-84. 
25. Davoodi J, Wakarchuk WW, Surewicz WK, Carey PR. Scan-rate dependence in protein calorimetry: the reversible transitions of Bacillus circulans xylanase and a disulfide-bridge mutant. Protein Sci. 1998; 7:1538-44. 
26. Davoodi J, Drown PM, Bledsoe RK, Wallin R, Reinhart GD, Hutson SM. Overexpression and characterization of the human mitochondrial and cytosolic branched-chain aminotransferases. J Biol Chem. 1998; 273: 4982-9.
27. Davoodi J, Wakarchuk WW, Campbell RL, Carey PR, Surewicz WK. Abnormally high pKa of an active-site glutamic acid residue in Bacillus circulans xylanase. The role of electrostatic interactions. Eur J Biochem. 1995; 232: 839-43. 
28. Rabbani A, Davoodi J. Effects of anthracycline antibiotic, daunomycin on thymus chromatin: the role of chromosomal proteins. Gen Pharmacol. 1994; 25: 787-93. 
29. Wakarchuk WW, Campbell RL, Sung WL, Davoodi J, Yaguchi M. (1994) Mutational and crystallographic analyses of the active site residues of the Bacillus circulans xylanase. Protein Sci. 1994; 3:467-75.

Davoodi, J., Hutson, S., and Grange R. (2015) Branched chain amino acids in inherited muscle disease: the case of Duchene muscular dystrophy in The Branched Chain Amino Acids in Clinical Nutrition, Springer, 2015, pages 277-287.
Davoodi J, Markert CD, Voelker KA, Hutson SM, Grange RW. Nutrition strategies to improve physical capabilities in Duchenne muscular dystrophy. Physical Medicine & Rehabilitation Clinics of North America, 2012, 23:187-99.

Selected Professional Activities:
  • Member of the scientific committee of the Third International Symposium in Molecular Technology (2009) Shahid Beheshti University of Medical Sciences.
  • Board of Directors of Proteomics Committee, (2007-2010) National Academy of Medical Sciences, Tehran, Iran
  • Research Advisory Board, (2007-2010), The Research Center of Gastroenterology & Liver transplantation, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  • Elected member for the Board of Directors of Iranian Cell Death Association (2007-2010)
  • Elected member for the Board of Directors of Iranian Proteomics Society (2014-Present)

Society Memberships:

  • American society of Biochemistry and Molecular Biology
  • Biophysical Society
  • Iranian Cell Death Society
  • Iranian Proteomics Society



  • Utilizing animals in teaching and research (IACUC)
  • Safety in the chemical laboratory
  • Blood borne pathogens
  • Radioactive material safety training

  • Enzymology
  • Advanced Topics in Biochemistry
  • Proteomics
  • Methods in Biochemistry