Khashayar Karimian

Dr. Khashayar Karimian

Khashayar Karimian

Professor

Ph.D. Bioorganic Chemistry, Louisiana State University, 1976

E-mail: kkarimian@arsato.com

ACADEMIC POSITIONS:

2013- Invited Member, Chemistry Branch of the Iranian Academy of Science

2010- Adjunct Professor, Department of Chemical Engineering, College of Engineering, University of Tehran

2002- Adjunct Professor of Biochemistry, Institute of Biochemistry and Biophysics, University of Tehran

1996-1999 Member, Grant Selection Committee (Chemistry and Biochemistry), National Science and Engineering Research Council (NSRC) of Canada.

1996-1999 Member, Grant Selection Committee for Major Instruments (Chemistry and Biochemistry), National Science and Engineering Research Council (NSERC) of Canada.

1985-1989 Visiting Professor and Lecturer, Department of Chemistry, University of Toronto

1979-1985 Assistant Professor of Biochemistry, Institute of Biochemistry and Biophysics, University of Tehran

INDUSTRIAL POSITIONS:

2015- Chairman, Ajand Pharmaceutical Holding Inc.

2014- President, Andisheh Pharmaceutical Sciences Research Center Inc.

2011- Vice President, Pharmaceutical Active ingredients, Chemicals and Packaging Material Syndicate (Iran)

2002-2012 Chairman and President, Arasto Pharmaceutical Chemicals Inc.

2002- Chairman, Avicenna Pharmaceuticals Inc.

1996-2003 Chief Scientific Officer, Medicinal Chemistry, Apotex Research Inc.

1996-1999 Head, Medicinal Chemistry, Apotex Inc.

1995-1996 General Manager, Fine Chemicals Division, Apotex Research Inc.

1994-1995 Director, Fine Chemicals Division, Apotex Research Inc.

1993-1994 Special Advisor, Apotex Inc.

1990-1992 Vice President, Scientific Affairs, ACIC (Canada) Inc.

1988-1990 Vice President, Research and Development, ACIC (Canada) Inc.

1986-1988 Director of Research and Development, ACIC (Canada) Inc.

1980-1984 Member of the Board of Directors, Iran Active Charcoal Company.

1979-1984 Consultant to the Board of Directors, Fine Chemicals Industries (TEMAD), Iranian Ministry of Health.

1979-1984 Consultant to the Board of Directors, Center for Pharmaceutical Research (DP).Iranian Ministry of Health.

GRANTS:

2017-2019 Presidential National Grants for Science-Based Companies (Arasto Pharmaceutical Chemicals Inc.) 24 Billion Rials (US $ 686,000),

2017-2019 Presidential National Grants for Science-Based Companies (Avicenna Laboratories Inc.) 14 Billion Rials (US $ 400,000),

2012-2015 Presidential National Major Research Grant 18 Billion Rials (US $ 1.6 Million),

"Industrial Production of 9 Anti-Cancer Active Pharmaceutical Ingredients and the Processes Thereof"

1998-2001 Ontario Research and Development Challenge Fund Grant No. 113-98UI CAN $ 750,000. Collaborative research with Dept. of Biophysics, University of Toronto, "Rational Design of Human Rhinovirous 3C Protease Inhibitors"

1998-2001 National Science and Engineering Research Council Grant No. CRD 661-104-97 CAN $ 190,000, Collaborative research with Dept. of Chemistry, University of Montreal, "Rational Design of Trans-glutaminase Inhibitors"

1995-1998 National Research Council, Industrial Research Assistance Program Grant No. 25323U CAN $ 1,050,000. Collaborative research with School of Medicine, McMaster University, "Rational Design of 1,2,4-thiadiazole: A Novel Class of Potential Therapeutics for the Treatment of Ulcer".

1989-1992 National Research Council, Industrial Research Assistance Program Grant No. 90765 CAN $ 80,000. Collaborative research with Cross Cancer Institute, University of Alberta, "Rational Design of 3'-Cyclocitidines: A Novel Class of Potential Anti-neoplastics".

1982-1985 Iranian Organization for Scientific and Industrial Research Grant CAN $ 30,000. "Economical Synthesis of Ara-C and Related Novel Anti-neoplastics".

1979-1982 University of Tehran Operating Grant No. 36-426 CAN $ 200,000. Institute of Biochemistry and Biophysics, University of Tehran, "Mechanism of Exchange of C-2 Proton in Thiazolium Salts".

1979-1980 Ministry of Science and Higher Education Grant No. 600-5-36-3 CAN $ 100,000. Institute of Biochemistry and Biophysics, University of Tehran, "Mechanism of Exchange of C-2 Proton in Thiazolium Salts".

Match	Document	Document Title	Score
1	WO/1991/004244A1	NADOLOL A process for making 5-{d-3-(tert-butylamino)-2-hydroxypropoxy}-1,2,3,4-tetrahydr o-1-cis-2,3 naphthalenediol of formula (I), by reacting formula (II) in an essentially water free environment with...	999
2	WO/1997/003971A1	PROCESS FOR THE MANUFACTURE OF BIS-TRIAZOLE COMPOUNDS AND INTERMEDIATES USEFUL IN THE MANUFACTURE THEREOF HAVING ANTIFUNGAL ACTIVITY A process to prepare a compound of formula (I) wherein Y and Z can be identical or different and represent a halogene. The bis-triazole compounds of formula (I) and intermediates have antifungal...	944
3	WO/1995/007895A1	METHODS FOR THE MANUFACTURE OF FLUCONAZOLE AND FORMS THEREOF, INTERMEDIATES USEFUL IN THE MANUFACTURE THEREOF, AND COMBINATIONS COMPRISING FLUCONAZOLE A process for making fluconazole comprising the steps shown above.	918
4	WO/2016/110761A1	PROCESS FOR PRODUCING 1-β-D-ARABINOFURANOSYLCYTOSINE AND 2,2'-O-CYCLOCYTIDINE An efficient and simple process is provided for producing 1-β-D-arabinofuranosylcytosine or cytarabine wherein cytidine hydrochloride is converted to the corresponding 2,2'-...	873
5	5817875	Methods for the manufacture of terbinafine Process for the manufacture of naphthylmethylamine derivatives and among them terbinafine as potential antimycotic agents.	866
6	WO/2016/097989A1	PROCESS FOR THE PREPARATION OF GEMCITABINE HYDROCHLORIDE The present invention relates to an improved as well as an industrially viable process for the preparation of 2'-deoxy-2',2'-difluorocytidine and its pharmaceutical acceptable acid salts thereof...	810
7	6046332	Methods for the manufacture of cetirizine The present invention relates to a process for the preparation of a [2-[4-[4-(chlorophenyl)phenylmethyl]-1-piperazinyl]ethoxy]ac etic acid derivative of formula I: and, in particular, for the...	798
8	WO/1994/005628A1	SYNTHESIS OF 2-SUBSTITUTED QUINAZOLINE COMPOUNDS (SUCH AS TERAZOSIN) AND MEOBENTINE AND BETHANIDINE AND INTERMEDIATES THEREFOR Novel methods for the synthesis of substituted ureas and guanidines including Terazosin, Prazosin, Doxazosin, Tiodazosin, Trimazosin, Quinasin and Bunazosin (exemplary of 2-amino substituted...	787
9	WO/1991/013900A1	PROCESS FOR PRODUCING 2,2'-O-CYCLONUCLEOSIDES, NUCLEOSIDES, AND ANALOGS THEREOF A novel process is provided for producing a nucleoside, such as cytarabine, or a nucleoside analogue, comprising the step of reacting 2,2'-O-cyclonucleoside or an analogue thereof with an amine....	750
10	WO/1998/002425A1	METHODS FOR THE MANUFACTURE OF CETIRIZINE A process for the manufacture of [2-[4-[4-(chlorophenyl)phenylmethyl]-1-piperazinyl]ethoxy]ac etic acid derivatives of formula (I) is provided.	750
11	DE69902212T2	Azithromycinmonohydrat-Isopropanol-Clathrate und Methoden zu deren Herstellung	721
12	DE69902212D1	Azithromycinmonohydrat-Isopropanol-Clathrate und Methoden zu deren Herstellung	721
13	6063933	Process for the manufacture of bis-triazole compounds and intermediates useful in the manufacture thereof having antifungal activity PCT No. PCT/CA96/00483 Sec. 371 Date Feb. 24, 1998 Sec. 102(e) Date Feb. 24, 1998 PCT Filed Jul. 17, 1996 PCT Pub. No. WO97/03971 PCT Pub. Date Feb. 6, 1997The present invention relates to a...	675
14	WO/1999/065892A1	PROCESS TO MANUFACTURE SIMVASTATIN AND INTERMEDIATES A process is disclosed for the preparation of simvastatin which enables highly regio selective C-methylation of the 2'-position group of lovastatin without requiring protection/deprotection of...	675
15	WO/2016/098015A1	NEW EFFICIENT METHODS FOR THE SYNTHESIS OF TAXANE DERIVATIVES SUCH AS DOCETAXEL AND THEIR STRUCTURAL ANALOGOUS, AND A METHOD FOR THE PREPARATION THEREOF The present invention relates to a novel process for the preparation of taxanes such as Docetaxel, a very important anticancer drug. Docetaxel 1 is a clinically well-established anti -mitotic...	675
16	WO/2004/083227A1	ISOPROPANOLATE OF AZITHROMYCIN AND METHOD OF MANUFACTURING Azithromycin isopropanolate of the empirical formula azithromycin: [H20]x: [isopropanol]y is obtained from the crystallization of azithromycin in isopropanol and water. The x and y values is...	625
17	WO/1991/013901A1	3'-O-TOSYLCYTIDINE AND CYTOSINE COMPOUNDS, AND PROCESS FOR PRODUCTION THEREOF Compounds of formula (IV), wherein R?6� is selected from the group comprising a trifluoromethyl group, a C�1?-C�6? alkyl group and a C�6?-C�9? aryl group, and R?1� is selected from the group...	625
18	EP0521923A1	PROCESS FOR PRODUCING NUCLEOSIDES, AND ANALOGS THEROF. Abstract not available for EP0521923 Abstract of corresponding document: WO9113900 A novel process is provided for producing a nucleoside, such as cytarabine, or a nucleoside analogue, comprising...	577
19	EP1087958A1	PROCESS TO MANUFACTURE SIMVASTATIN AND INTERMEDIATES	577
20	EP0840730A1	PROCESS FOR THE MANUFACTURE OF BIS-TRIAZOLE COMPOUNDS AND INTERMEDIATES USEFUL IN THE MANUFACTURE THEREOF HAVING ANTIFUNGAL ACTIVITY Abstract not available for EP0840730 Abstract of corresponding document: US6063933 PCT No. PCT/CA96/00483 Sec. 371 Date Feb. 24, 1998 Sec. 102(e) Date Feb. 24, 1998 PCT Filed Jul. 17, 1996 PCT...	577
21	EP1058690A1	THIADIAZOLE COMPOUNDS USEFUL AS INHIBITORS OF CYSTEINE ACTIVITY DEPENDENT ENZYMES	577
22	EP0984020B1	Azithromycin monohydrate isopropanol clathrate and methods for the manufacture thereof. Abstract of EP0984020 A novel form of azithromycin and processes for preparation of pure azithromycin monohydrate isopropanol clathrate (3 molecules of isopropanol for every 10 molecules of...	577
23	EP0445250A1	Process for preparing nadolol. Abstract not available for EP0445250 Abstract of corresponding document: US5319141 PCT No. PCT/CA90/00316 Sec. 371 Date May 20, 1991 Sec. 102(e) Date May 20, 1991 PCT Filed Sep. 25, 1990 PCT Pub....	577
24	EP0523080A1	3'-O-TOSYLCYTIDINE AND CYTOSINE COMPOUNDS, AND PROCESS FOR PRODUCTION THEREOF. Abstract not available for EP0523080 Abstract of corresponding document: US5399682 PCT No. PCT/CA91/00078 Sec. 371 Date Oct. 5, 1992 Sec. 102(e) Date Oct. 5, 1992 PCT Filed Mar. 13, 1991 PCT Pub....	577
25	EP0984020A3	Azithromycin monohydrate isopropanol clathrate and methods for the manufacture thereof. Abstract of EP0984020 A novel form of azithromycin and processes for preparation of pure azithromycin monohydrate isopropanol clathrate (3 molecules of isopropanol for every 10 molecules of...	577
26	DE69712608D1	PROTONENPUMPINHIBITOREN	577
27	DE69015151D1	Verfahren zur Herstellung von Nadolol.	577
28	DE69712608T2	PROTONENPUMPINHIBITOREN	577
29	DE69108014T2	VERFAHREN ZUR HERSTELLUNG VON NUCLEOSIDEN UND IHRE ANALOGEN.	577
30	DE69902788T2	VERFAHREN ZU HERSTELLUNG VON SIMVASTATIN UND ZWISCHENPRODUKTEN	577
31	DE69015151T2	Verfahren zur Herstellung von Nadolol.	577
32	DE69111438D1	2,3'-O-CYCLOCYTIDINE UND VERFAHREN ZU DEREN HERSTELLUNG.	577
33	DE69108014D1	VERFAHREN ZUR HERSTELLUNG VON NUCLEOSIDEN UND IHRE ANALOGEN.	577
34	DE69111438T2	2,3'-O-CYCLOCYTIDINE UND VERFAHREN ZU DEREN HERSTELLUNG.	577
35	DE69902788D1	VERFAHREN ZU HERSTELLUNG VON SIMVASTATIN UND ZWISCHENPRODUKTEN	577
36	WO/2001/090095A1	THIADIAZOLE COMPOUNDS USEFUL AS INHIBITORS OF CYSTEINE ACTIVITY DEPENDENT ENZYMES Novel 1,2,4-thiadiazole compounds are provided, which are effective as inhibitors of cysteine activity-dependent enzymes and in particular of cysteine proteases. The compounds are useful in...	540
37	5399682	Process for preparing 2,3'-O-cyclocytidine A process for preparing 2,3'-O-cyclocytidine wherein 3'-deoxy-3'-organosulfonyl cytidine is refluxed in the absence of base. 2,3'-cyclocytidine is an intermediate in the preparation of...	530
38	6245903	Azithromycin monohydrate isopropanol clathrate and methods for the manufacture thereof A novel form of azithromycin and processes for preparation of pure azithromycin monohydrate isopropanol clathrate (3 molecules of isopropanol for every 10 molecules of azithromycin monohydrate)...	530
39	6162791	Thiadiazole compounds useful as inhibitors of cysteine activity dependent enzymes Novel 1,2,4-thiadiazole compounds are provided, which are effective as inhibitors of cysteine activity-dependent enzymes and in particular of cysteine proteases. The compounds are useful in...	505
40	6060472	Thiadiazole compounds useful as inhibitors of H+ /K+ atpase Novel 3,5-disubstituted 1,2,4-thiadiazole compounds are provided, which are effective in treating peptic ulcers by the inhibition of H+ /K+ -ATPase. The compounds of the present invention are...	505
41	US20060183890	Isopropanolate of azithromycin and method of manufacturing Azithromycin isopropanolate of the empirical formula azithromycin:[H20]x:[isopropanol]y is obtained from the crystallization of azithromycin in isopropanol and water. The x and y values is...	505
42	5847118	Methods for the manufacture of amorphous cefuroxime axetil A process for preparing pure amorphous cefuroxime axetil comprising the steps of dissolving crystalline cefuroxime axetil in a highly polar organic solvent and adding the resulting solution to...	505
43	EP1087958B1	PROCESS TO MANUFACTURE SIMVASTATIN AND INTERMEDIATES	505
44	EP0883606A1	PROCESS FOR SCAVENGING THIOLS Abstract not available for EP0883606 Abstract of corresponding document: WO9731893 Thiols are trapped, and converted to disulfide compounds, by a process of reacting them with compounds containing...	505
45	EP0521923B1	PROCESS FOR PRODUCING NUCLEOSIDES, AND ANALOGS THEROF Abstract not available for EP0521923 Abstract of corresponding document: WO9113900 A novel process is provided for producing a nucleoside, such as cytarabine, or a nucleoside analogue, comprising...	505
46	EP0445250B1	Process for preparing nadolol Abstract not available for EP0445250 Abstract of corresponding document: US5319141 PCT No. PCT/CA90/00316 Sec. 371 Date May 20, 1991 Sec. 102(e) Date May 20, 1991 PCT Filed Sep. 25, 1990 PCT Pub....	505
47	EP0984020A2	Azithromycin monohydrate isopropanol clathrate and methods for the manufacture thereof. A novel form of azithromycin and processes for preparation of pure azithromycin monohydrate isopropanol clathrate (3 molecules of isopropanol for every 10 molecules of azithromycin monohydrate)...	505
48	EP0883622A1	PROTON PUMP INHIBITOR Abstract not available for EP0883622 Abstract of corresponding document: US5677302 Novel thiadiazole compounds are provided, which are effective as proton pumps inhibitors, useful in treating...	505
49	EP0656885A1	SYNTHESIS OF 2-SUBSTITUTED QUINAZOLINE COMPOUNDS (SUCH AS TERAZOSIN) AND MEOBENTINE AND BETHANIDINE AND INTERMEDIATES THEREFOR. Abstract not available for EP0656885 Abstract of corresponding document: WO9405628 Novel methods for the synthesis of substituted ureas and guanidines including Terazosin, Prazosin, Doxazosin,...	505
50	6093738	Proton pump inhibitors Novel thiadiazole compounds are provided, which are effective as proton pumps inhibitors, useful in treating peptic ulcers by inhibition of the proton pump enzyme H+ /K+ -ATPase. The compounds are...	500

Match	Document	Document Title	Score
51	5610292	Process for producing 2,2'-o-cyclonucleosides nucleosides, and analogs thereof A novel process is provided for producing a nucleoside, such as cytarabine, or a nucleoside analogue, comprising the step of reacting 2,2'-O-cyclonucleoside or an analogue thereof with an amine....	484
52	WO/1995/021183A1	HALOGENATED DERIVATIVES OF 2,3'-O-CYCLOCYTIDINE COMPOUNDS AND PROCESS FOR PRODUCTION THEREOF In one of its aspects, the present invention provides novel compounds of formula (I) wherein: X is a halide; Y is selected from the group consisting essentially of halide, sulfate, acetate, tosyl,...	435
53	RE39087	Azithromycin monohydrate isopropanol clathrate and methods for the manufacture thereof A novel form of azithromycin and processes for preparation of pure azithromycin monohydrate isopropanol clathrate (3 molecules of isopropanol for every 10 molecules of azithromycin monohydrate)...	433
54	5319141	Process of making nadolol A process for making 5-(d-3-(tert-butylamino)-2-hydroxypropoxy)-1,2,3,4-tetrahydr o-1-cis-2,3 naphthalenediol of the formula ##STR1## by reacting ##STR2## in an essentially water free environment...	433
55	5536824	Organosulfonyl salts of 2,3'-O-cyclocytidine Compounds of Formula IV: ##STR1## are described. In the compounds of Formula IV, R6 is selected from a trifluoromethyl group, a C1 -C6 alkyl group and a C6 -C9 aryl group, and R1 is selected from...	433
56	6468977	Thiadiazole compounds useful as inhibitors of cysteine activity dependent enzymes Novel 1,2,4-thiadiazole compounds are provided, which are effective as inhibitors of cysteine activity-dependent enzymes and in particular of cysteine proteases. The compounds are useful in...	433
57	EP0523080B1	2,3'-O-CYCLOCYTIDINES, AND PROCESS FOR PRODUCTION THEREOF Abstract not available for EP0523080 Abstract of corresponding document: US5399682 PCT No. PCT/CA91/00078 Sec. 371 Date Oct. 5, 1992 Sec. 102(e) Date Oct. 5, 1992 PCT Filed Mar. 13, 1991 PCT Pub....	433
58	WO/1997/031893A1	PROCESS FOR SCAVENGING THIOLS Thiols are trapped, and converted to disulfide compounds, by a process of reacting them with compounds containing a 1,2,4-thiadiazole ring structure carrying a substituent at position 3 of the...	433
59	WO/1997/031923A1	PROTON PUMP INHIBITOR Novel thiadiazole compounds are provided, which are effective as proton pumps inhibitors, useful in treating peptic ulcers by inhibition of the proton pump enzyme H+/K+-ATPase. The compounds are...	433
60	EP1615941A1	ISOPROPANOLATE OF AZITHROMYCIN AND METHOD OF MANUFACTURING Abstract not available	408
61	EP0550714A1	NOVEL ANTI-VIRAL COMPOUNDS AND PROCESSES FOR PRODUCTION OF ANTI-VIRAL COMPOUNDS. Abstract not available for EP0550714 Abstract of corresponding document: WO9300351 A process for recovering zidovudine or a derivative thereof from a mixture of chemicals comprising zidovudine or...	408
62	WO/1993/000351A1	NOVEL ANTI-VIRAL COMPOUNDS AND PROCESSES FOR PRODUCTION OF ANTI-VIRAL COMPOUNDS A process for recovering zidovudine or a derivative thereof from a mixture of chemicals comprising zidovudine or a derivative thereof. The process comprises the steps of: (i) reacting zidovudine...	408
63	DE550714T1	Antiviralverbindungen und Ihrer Verfahren zur Herstellung.	408
64	DE69208636D1	VERFAHREN ZUR HERSTELLUNG VON ZIDOVUDINE	408
65	DE69208636T2	VERFAHREN ZUR HERSTELLUNG VON ZIDOVUDINE	408
66	5527782	5-halo-2,3'-O-cyclocytidines A 5'-halo-2,3'-O-cyclocytidine of Formula I: ##STR1## wherein: X is a bromide, chloride, or iodide;Y is halide, sulfate, acetate, tosyl, mesyl, benzoate, and phosphate;R1 is hydrogen; andR2 is a...	388
67	6506929	Process to manufacture simvastatin and intermediates A process is disclosed for the preparation of simvastatin which enables highly regio selective C-methylation of the 2′-position group of lovastatin without requiring protection/deprotection of...	360
68	5686612	Methods of making ureas and guanidines, including terazosin, prazosin, doxazosin, tiodazosin, trimazosin, quinazosin, and bunazosin (exemplary of 2-substituted quinazoline compounds), and meobentine, and bethanidine and intermediates thereof Novel methods for the synthesis of substituted ureas and guanidines including Terazosin, Prazosin, Doxazosin, Tiodazosin, Trimazosin, Quinasin and Bunazosin (exemplary of 2-amino substituted...	360
69	EP0883622B1	PROTON PUMP INHIBITOR Abstract not available for EP0883622 Abstract of corresponding document: US5677302 Novel thiadiazole compounds are provided, which are effective as proton pumps inhibitors, useful in treating...	360
70	WO/1999/045027A1	THIADIAZOLE COMPOUNDS USEFUL AS INHIBITORS OF CYSTEINE ACTIVITY DEPENDENT ENZYMES Novel 1,2,4-thiadiazole compounds are provided, which are effective as inhibitors of cysteine activity-dependent enzymes and in particular of cysteine proteases. The compounds are useful in...	360
71	US20030225007	Sulfonamide derivatives of 3-substituted imidazol[1,2-d]-1,2,4-thiadiazoles and 3-substituted-[1,2,4] thiadiazolo[4,5-a] benzimidazole as inhibitors of fibrin cross-linking and transglutaminases A method of inhibiting the activity of transglutaminases containing a cysteine residue comprising administering to a mammal an effective amount of a sulfonamide derivative of...	357
72	EP0550714B1	PROCESSES FOR PRODUCTION OF ZIDOVUDINE Abstract not available for EP0550714 Abstract of corresponding document: WO9300351 A process for recovering zidovudine or a derivative thereof from a mixture of chemicals comprising zidovudine or...	357
73	EP1348710A1	Sulfonamide derivatives of 3-substituted imidazo[1,2-D]-1,2,4-thiadiazoles and 3-substituted-[1,2,4]thiadiazolo[4,5-A]benzimidazole as inhibitors of fibrin cross-linking and transglutaminases A method of inhibiting the activity of transglutaminases containing a cysteine residue comprising administering to a mammal an effective amount of a sulfonamide derivative of...	357
74	5677302	Thiadiazole compounds useful as proton pump inhibitors Novel thiadiazole compounds are provided, which are effective as proton pumps inhibitors, useful in treating peptic ulcers by inhibition of the proton pump enzyme H+ /K+ -ATPase. The compounds are...	353
75	5596093	Process for preparing halogenated 2,3-O-cyclocytidine derivatives A process from preparing 5-halogenated 2,3-O-cyclocytidine derivatives comprising reacting 2,3-O-cyclocytidine with a halogenating reagent, preferably N-bromosuccinimide, in the presence of an...	333
76	5723618	1,4-dihydropyridines, N-substituted bicyclic 4-hydropyridines, and bicyclic N-substituted 4,5-dihydropyridines The invention relates to a novel process to prepare 1,4-dihydropyridines and in particular amlopidine and in novel intermediates obtained during the synthesis of the 1,4-dihydropyridines which...	306
77	5914401	Methods for the manufacture of quinolone carboxylic acids derivatives and intermediates thereof Novel process for the preparation of quinolone carboxylic acid derivatives of general formula I, and intermediates thereof as illustrated in Scheme 1 wherein the key intermediate is a compound of...	306
78	5900485	Methods for the manufacture of neofazodone Process for the manufacture of triazolone compounds and in particular nefazodone and intermediates useful in the manufacture thereof.	306
79	6114537	Process for scavenging thiols Thiols are trapped, and converted to disulfide compounds, by a process of reacting them with compounds containing a 1,2,4-thiadiazole ring structure carrying a substituent at position 3 of the...	288
80	5675006	Methods of making ureas and guanidines, including, terazosin, prazosin, doxazosin, tiodazosin, trimazosin, quinazosin, and bunazosin (exemplary of 2- substituted quinazoline compounds), and meobentine, and bethanidine and intermediates therefor Novel methods for the synthesis of substituted ureas and guanidines including Terazosin, Prazosin, Doxazosin, Tiodazosin, Trimazosin, Quinasin and Bunazosin (exemplary of 2-amino substituted...	288
81	6080860	Methods of making ureas and guanidines including, terazosin, prazosin, doxazosin, tiodazosin, trimazosin, quinazosin and bunazosin (exemplary of 2-substituted quinazoline compounds), and meobentine, and bethanidine and intermediates therefor Novel methods for the synthesis of substituted ureas and guanidines including Terazosin, Prazosin, Doxazosin, Tiodazosin, Trimazosin, Quinasin and Bunazosin (exemplary of 2-amino substituted...	288
82	5387677	Recovery of AZT by guanidine precipitation A process for recovering 3'-azido-3'-deoxythymidine (AZT) or a salt thereof from a mixture of chemicals involving the reaction of the AZT with guanidine to form a salt precipitate. The salt...	255
83	5519129	Complex of guanidine and AZT A composition of a 1:1 molar complex of guanidine and 3'-azido-3'-deoxythymidine (AZT) which is generated at about pH above 9 and disrupted by pH below about 9. This complex is a useful...	255

No	Product	No	Product
1	Acyclovir	31	Erlotinib
2	Alendronate Sodium	32	Etidronate Disodium
3	Amitriptyline HCl	33	Fluconazol
4	Amlodipine	34	Fluoxetine HCl
5	Astemizole	35	Gemcytabine
6	Atenolol	36	Imatinib
7	Azathioprine	37	Ketoconozole
8	Azithromycin	38	Lactulose (solution)
9	AZT (Ziduvudine)	39	Lamotrigine
10	Bortezomib	40	Loratidine
11	Buspirone	41	Lovastatin
12	Capecitabine	42	2-Methylmercaptophenothiazine
13	Captopril	43	Methacholine Chloride
14	Carbamazapine	44	Methylphenidate
15	Carbidopa	45	Montelukast
16	Celecoxib	46	Nadolol
17	2-Chlorophenothiazine	47	Nefazodone
18	Cefuroxime Acxetil	48	Nifedipine
19	Ciprofluxacin	49	Norfluxacin
20	Cimitidine	50	Nortriptyline HCl
21	Citirizine	51	Omeprazole
22	Clomipramine HCl	52	Pantoprazole
23	Cyclosporin	53	Ranitidine
24	Cytarabine	54	Simvaststin
24	Deferasirox	55	Sunitinib
26	Deferiprone	56	Temzolamide
27	Dipivefrine	57	Terbinafine
28	Docetaxol	58	Terazosin
29	Domperidon	59	Vorinostat
30	Doxazosin	60	Warfarin Na/IPA Clathrate

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